The right Mayo Clinic phone number depends on your request. Use the location’s appointment office for scheduling, 844-217-9591 for Patient Account Services billing questions, and 877-858-0398 for patient-portal assistance. This guide helps route contact requests; it does not provide medical advice or arrange care.
Mayo Clinic Contact Numbers by Department
| Request | Phone |
|---|---|
| Arizona appointments | 480-301-8484 |
| Florida appointments — Jacksonville | 904-953-0853 |
| Minnesota appointments — Rochester | 507-538-3270 |
| Billing — Patient Account Services | 844-217-9591 |
| Patient-portal technical assistance | 877-858-0398 |
Appointment numbers are listed in Mayo Clinic’s official contact directory. Billing and portal contacts are confirmed on its Patient Account Services page and portal-assistance information. Use the directory to locate another office rather than assuming one number handles every campus.
Appointments and Scheduling Questions
Contact the appointment office for the campus you want. Explain whether this is a new appointment request, a change to an existing visit or a question about scheduling instructions. Keep the appointment confirmation and the department name available when following up.
For a local Mayo Clinic Health System facility, use that facility’s own contact information. Do not assume the Rochester appointment line is the right route for every location. A request for an appointment is not confirmation of a booked visit; retain the scheduling confirmation you receive.
Billing and Patient Account Services
Use 844-217-9591 for questions about statements, balances and financial assistance. Mayo also offers a secure-message route through the patient portal. Its billing contact page lists Central Time hours: Monday–Thursday, 7 a.m.–7 p.m. during daylight saving time or 7 a.m.–6 p.m. during standard time; Friday, 7 a.m.–4 p.m. year-round.
Have the statement, service date and payment or insurance correspondence ready. State whether you need an explanation of a charge, a payment-status check or information about assistance. Ask which team will handle the next step and retain the reference number.
Patient-Portal Login and Technical Help
For portal access or technical trouble, call 877-858-0398 or use Mayo’s patient-portal assistance page. Describe the error, the device or browser, and whether you are using the app or website.
A technical-help request is separate from a message to your care team. Send medical questions through the appropriate clinical route. For an emergency, call 911 or your local emergency number; do not wait for a portal or directory response.
Mayo Clinic Contact FAQs
Is there one Mayo Clinic number for everything?
No. Appointment, billing and portal assistance have different contacts. Start with the department and location relevant to the request.
Which number handles Mayo Clinic billing questions?
Patient Account Services is available at 844-217-9591.
Who can help if I cannot access the patient portal?
Call portal assistance at 877-858-0398 or use Mayo’s online assistance page.
Can the portal technical team book an appointment?
Use the appropriate appointment office for scheduling; the portal-help route is for access and technical questions.
What should I keep ready for a billing call?
Keep the statement, service date and relevant payment or insurance correspondence available. Share identifying details only through official channels.
Can I ask Mayo Clinic a medical question in a CSN review?
No. Public reviews are not monitored clinical messages. Contact your care team directly and keep private health information out of reviews.
Share Your Mayo Clinic Support Experience
Read customer reviews or leave your own review. Describe the issue, the contact route you tried and whether it was resolved. Keep diagnoses, medical records, patient numbers and other private health information out of public reviews. A review here does not open a support case.
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About This Guide
CustomerServiceNumbers.com is an independent directory and review website, not Mayo Clinic support. We link to official sources and provide practical suggestions for preparing a request. We cannot access accounts, arrange care or resolve medical or billing matters.
Official contact routes checked October 23, 2026. Options, hours and policies can change; follow the current instructions on the linked official pages.